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Tri doze istog cjepiva protiv covida-19 ili kombinacija triju različitih cjepiva jednako dobro djeluju na prevenciju infekcije, pokazala je najveća dosad provedena studija ovog tipa, piše Guardian. 


Premda je učinkovitost pojedinačnih cjepiva protiv koronavirusa dobro poznata, manje je dokaza o djelotvornosti kombinacije raznih cjepiva, osobito kad je riječ o određenim dobnim skupinama, poput starijih ljudi ili imunokompromitiranih skupina.


Ključan broj dobivenih doza, a ne kombinacija cjepiva
Najnovija globalna analiza podataka u sklopu koje su proučeni podaci o više od 100 milijuna ljudi u svijetu, potvrdila je da je za jačanje imuniteta ključan broj dobivenih doza, a ne o kakvoj je kombinaciji cjepiva riječ.
Rezultati analize objavljeni su u časopisu British Medical Journal (BMJ).
Studija je pokazala da tri doze cjepiva, bilo da se radi o istoj vrsti ili kombinaciji različitih cjepiva, djeluju jednako dobro u prevenciji infekcije covidom-19, čak i kada je riječ o različitim sojevima i varijantama.


Unatoč tomu što je globalno puno manje zaraza koronavirusom i smrtnih ishoda od posljedica covida-19, važno je shvatiti koje su kombinacije cjepiva najučinkovitije  zbog pojave novih varijanti koronavirusa i zbog brzog slabljenja imunološke zaštite relativno kratko nakon cijepljenja, odnosno smanjenja razine postignutih antitijela nedugo nakon cijepljenja, pojasnili su znanstvenici u BMJ.

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Znanstvenici s Kineskog sveučilišta u Hong Kongu (CUHK) pretražili su 38 baza podataka Svjetske zdravstvene organizacije o covidu-19 tražeći dosad objavljene studije na tjednoj bazi.


Globalna analiza 53 studija s podacima o 100 milijuna cijepljenih  
Pronašli su i proučili 53 studije u koje je bilo uključeno 100 milijuna ljudi cijepljenih 24-ima kombinacijama cjepiva protiv covida.
Primanje triju doza istog cjepiva poznato je kao homologni režim cijepljenja, a kada se kao 'booster' primi treća doza cjepiva koje je različito od prvih dviju, govorimo o heterolognom režimu.


Nakon što su uzeli u obzir razlike u kvaliteti i tipu studije, istraživači CUHK-a su otkrili da tri doze bilo kojeg cjepiva na bazi glasničke RNK (mRNK) omogućuju najučinkovitiju zaštitu - čak 96 posto u slučaju umjereno teških infekcija covida-19, kao i da su najučinkovitije (95 posto) kada je posrijedi hospitalizacija oboljelih zbog posljedica covida-19. 
No rezultati su pokazali i da bilo koji režim cijepljenja trima dozama, bilo da se radi o heterolognom ili homolognom, potiče snažniji imunitet u svim dobnim skupinama, čak i u starijih od 65 godina, u odnosu na homologni režim, dakle u slučaju cijepljenja samo dvjema dozama.


Studija je pokazala i da u slučaju imunokompromitiranih pacijenata treća 'booster' doza mRNK cjepiva, bilo da je riječ o heterolognom ili homolognom režimu cijepljenja, također uvelike poboljšava zaštitu u usporedbi s dvjema primljenim dozama.
Učinkovitost cijepljenja trima dozama cjepiva, kada se radi o smrtnom ishodu zbog covida-19 još uvijek nije utvrđena. 
Znanstvenici su ukazali na neka ograničenja studije. U svojoj analizi nisu procijenili optimalne intervale za primanje 'boostera' zbog ograničenih informacija.


“Preporučuje se mRNK 'booster' kao dopunsko cijepljenje nakon bilo kojeg primarnog cjepiva. Heterologni i homologni režimi trima dozama djeluju jednako dobro u prevenciji zaraze covidom-19, čak i u slučaju različitih varijanti koronavirusa", zaključili su. 

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Tri doze istog cjepiva protiv covida-19 ili kombinacija triju različitih cjepiva jednako dobro djeluju na prevenciju infekcije, pokazala je najveća dosad provedena studija ovog tipa, piše Guardian. 


Premda je učinkovitost pojedinačnih cjepiva protiv koronavirusa dobro poznata, manje je dokaza o djelotvornosti kombinacije raznih cjepiva, osobito kad je riječ o određenim dobnim skupinama, poput starijih ljudi ili imunokompromitiranih skupina.


Ključan broj dobivenih doza, a ne kombinacija cjepiva
Najnovija globalna analiza podataka u sklopu koje su proučeni podaci o više od 100 milijuna ljudi u svijetu, potvrdila je da je za jačanje imuniteta ključan broj dobivenih doza, a ne o kakvoj je kombinaciji cjepiva riječ.
Rezultati analize objavljeni su u časopisu British Medical Journal (BMJ).
Studija je pokazala da tri doze cjepiva, bilo da se radi o istoj vrsti ili kombinaciji različitih cjepiva, djeluju jednako dobro u prevenciji infekcije covidom-19, čak i kada je riječ o različitim sojevima i varijantama.


Unatoč tomu što je globalno puno manje zaraza koronavirusom i smrtnih ishoda od posljedica covida-19, važno je shvatiti koje su kombinacije cjepiva najučinkovitije  zbog pojave novih varijanti koronavirusa i zbog brzog slabljenja imunološke zaštite relativno kratko nakon cijepljenja, odnosno smanjenja razine postignutih antitijela nedugo nakon cijepljenja, pojasnili su znanstvenici u BMJ.

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Znanstvenici s Kineskog sveučilišta u Hong Kongu (CUHK) pretražili su 38 baza podataka Svjetske zdravstvene organizacije o covidu-19 tražeći dosad objavljene studije na tjednoj bazi.


Globalna analiza 53 studija s podacima o 100 milijuna cijepljenih  
Pronašli su i proučili 53 studije u koje je bilo uključeno 100 milijuna ljudi cijepljenih 24-ima kombinacijama cjepiva protiv covida.
Primanje triju doza istog cjepiva poznato je kao homologni režim cijepljenja, a kada se kao 'booster' primi treća doza cjepiva koje je različito od prvih dviju, govorimo o heterolognom režimu.


Nakon što su uzeli u obzir razlike u kvaliteti i tipu studije, istraživači CUHK-a su otkrili da tri doze bilo kojeg cjepiva na bazi glasničke RNK (mRNK) omogućuju najučinkovitiju zaštitu - čak 96 posto u slučaju umjereno teških infekcija covida-19, kao i da su najučinkovitije (95 posto) kada je posrijedi hospitalizacija oboljelih zbog posljedica covida-19. 
No rezultati su pokazali i da bilo koji režim cijepljenja trima dozama, bilo da se radi o heterolognom ili homolognom, potiče snažniji imunitet u svim dobnim skupinama, čak i u starijih od 65 godina, u odnosu na homologni režim, dakle u slučaju cijepljenja samo dvjema dozama.


Studija je pokazala i da u slučaju imunokompromitiranih pacijenata treća 'booster' doza mRNK cjepiva, bilo da je riječ o heterolognom ili homolognom režimu cijepljenja, također uvelike poboljšava zaštitu u usporedbi s dvjema primljenim dozama.
Učinkovitost cijepljenja trima dozama cjepiva, kada se radi o smrtnom ishodu zbog covida-19 još uvijek nije utvrđena. 
Znanstvenici su ukazali na neka ograničenja studije. U svojoj analizi nisu procijenili optimalne intervale za primanje 'boostera' zbog ograničenih informacija.


“Preporučuje se mRNK 'booster' kao dopunsko cijepljenje nakon bilo kojeg primarnog cjepiva. Heterologni i homologni režimi trima dozama djeluju jednako dobro u prevenciji zaraze covidom-19, čak i u slučaju različitih varijanti koronavirusa", zaključili su. 

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ZdravljeNOVA STUDIJA

Proučeni podaci o više od 100 milijuna ljudi u svijetu: tri doze cjepiva protiv covida najbolja su zaštita od infekcije

Piše HINA
6. lipnja 2022. - 11:10
22310980
PREMIUM
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Tri doze istog cjepiva protiv covida-19 ili kombinacija triju različitih cjepiva jednako dobro djeluju na prevenciju infekcije, pokazala je najveća dosad provedena studija ovog tipa, piše Guardian. 


Premda je učinkovitost pojedinačnih cjepiva protiv koronavirusa dobro poznata, manje je dokaza o djelotvornosti kombinacije raznih cjepiva, osobito kad je riječ o određenim dobnim skupinama, poput starijih ljudi ili imunokompromitiranih skupina.


Ključan broj dobivenih doza, a ne kombinacija cjepiva
Najnovija globalna analiza podataka u sklopu koje su proučeni podaci o više od 100 milijuna ljudi u svijetu, potvrdila je da je za jačanje imuniteta ključan broj dobivenih doza, a ne o kakvoj je kombinaciji cjepiva riječ.
Rezultati analize objavljeni su u časopisu British Medica...

#CJEPIVO COVID-19#NOVA STUDIJA
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20. svibanj 2024 01:14